Daxid (Sertraline HCl)
Also sold as: Daxid, Zoloft, Serlift, Sertima
Pregnancy
Cat C
Lactation
Caution
Schedule
H
Forms
Tablet 25/50/100mg
Indications
- MDD
- OCD
- Panic
- PTSD
- Social anxiety
- PMDD
Adult Dosing
All
Start 25-50 mg OD; titrate to 100-200 mg/day
Pediatric Dosing
Age Range: >6 years (OCD only)
Dose: Start 25 mg, titrate to 50-200 mg/day
Renal Dose Adjustment
| CrCl / eGFR | Dose Adjustment |
|---|---|
| No adjustment needed | No CrCl-based adjustment |
Hepatic Adjustment
Reduce dose / increase interval in severe
Pregnancy & Lactation
Pregnancy: Category C
Most studied SSRI in pregnancy; small PPHN/withdrawal risk in 3rd trimester
Lactation: Caution
Top Drug Interactions
| Interacting Drug | Effect | Severity |
|---|---|---|
| MAOIs | CONTRAINDICATED | Major |
| Tramadol, triptans, linezolid, methylene blue | Serotonin syndrome | Major |
| NSAIDs, anticoagulants | Bleeding risk | Major |
| Pimozide | CONTRAINDICATED — QT | Major |
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Side Effects
Common
- Diarrhea (common)
- Nausea
- Insomnia
- Sexual dysfunction
- Sweating
Serious / Discontinue If
- Suicidality (early, <25y)
- Serotonin syndrome
- Hyponatremia (elderly, SIADH)
- Bleeding
- Withdrawal on abrupt stop
Contraindications
- MAOI/pimozide
- Hypersensitivity
Available Indian Brands
| Brand | Manufacturer | Price (approx) |
|---|---|---|
| Daxid 50 | Sun Pharma | 10 tab ₹65 |
| Serlift 50 | Ranbaxy | 10 tab ₹85 |
| Zoloft 50 | Pfizer | 10 tab ₹185 |
Monitoring Required
- Mood, suicidality, Na+ in elderly
Patient Counseling Points
- Effect at 4-6 weeks
- Do not stop abruptly
- Avoid alcohol
- Report mood worsening
Stop Googling drug references mid-consultation
EasyClinic auto-flags Daxid interactions, renal cutoffs, and pregnancy warnings the moment you write the prescription. Built-in safety net for every Indian doctor.
References
- BNF
- Lexicomp
- Indian National Formulary
- Specialty society guidelines
Disclaimer: This information is for clinical reference only. It is not exhaustive and does not substitute clinical judgement. Always verify current dosing against the manufacturer's prescribing information and current treatment guidelines. Drug prices are approximate and may vary.