EasyClinic Drug Reference

Indian clinical drug database

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All Drugs

Statin · HMG-CoA reductase inhibitor (potent)

Crestor (Rosuvastatin Calcium)

Also sold as: Crestor, Rosuvas, Rozavel, Roseday

Pregnancy

Cat X

Lactation

Avoid

Schedule

Forms

Tablet 5/10/20/40mg

Indications

Hyperlipidemia
Primary prevention CVD (high ASCVD risk)
Secondary prevention
FH

Adult Dosing

Moderate intensity

5-10 mg PO OD

High intensity

20-40 mg PO OD

South Asian / elderly

Start 5 mg (Indian patients more sensitive — myopathy risk)

Maximum daily dose: 40 mg/day

Renal Dose Adjustment

CrCl / eGFR	Dose Adjustment
CrCl > 30	No adjustment
CrCl < 30	Start 5 mg, max 10 mg/day

Calculate eGFR / CrCl →

Hepatic Adjustment

CONTRAINDICATED in active liver disease

Pregnancy & Lactation

Pregnancy: Category X

CONTRAINDICATED — discontinue 3 months pre-conception

Lactation: Avoid

Top Drug Interactions

Interacting Drug	Effect	Severity
Cyclosporine	Major rosuva increase — limit to 5 mg	Major
Gemfibrozil	Myopathy risk	Major
Warfarin	Increased INR	Moderate
Antacids (Mg/Al)	Reduced absorption — separate by 2h	Minor

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Side Effects

Common

Myalgia
Headache
GI upset
Mild ALT elevation

Serious / Discontinue If

Rhabdomyolysis (more in Asian patients at high doses)
Hepatotoxicity
Proteinuria/hematuria (transient)

Contraindications

Active liver disease
Pregnancy/lactation

Available Indian Brands

Brand	Manufacturer	Price (approx)
Crestor 10	AstraZeneca	10 tab ₹245
Rozavel 10	Sun Pharma	10 tab ₹85
Rosuvas 10	Ranbaxy	10 tab ₹95

Monitoring Required

Lipid panel at 6 weeks, LFT only if symptomatic, CK if myalgia

Patient Counseling Points

Any time of day
Report unexplained muscle pain, dark urine
Indian patients should typically start at lower dose (5 mg)

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References

BNF
Lexicomp
Indian National Formulary
Specialty society guidelines

Disclaimer: This information is for clinical reference only. It is not exhaustive and does not substitute clinical judgement. Always verify current dosing against the manufacturer's prescribing information and current treatment guidelines. Drug prices are approximate and may vary.