Cardace (Ramipril)
Also sold as: Cardace, Ramistar, Ramipres, Hopace
Pregnancy
Cat D
Lactation
Caution
Schedule
H
Forms
Tablet 1.25/2.5/5/10mg +1
Indications
- HTN
- Heart failure
- Post-MI LV dysfunction
- Diabetic nephropathy
- CV risk reduction (HOPE trial)
Adult Dosing
HTN
2.5-10 mg PO OD; titrate every 2-4 weeks
HF
Start 1.25 mg BD; titrate to 5 mg BD
CV risk reduction
10 mg PO OD
Renal Dose Adjustment
| CrCl / eGFR | Dose Adjustment |
|---|---|
| CrCl > 30 | No adjustment |
| CrCl 10-30 | Max 5 mg/day, start 1.25 mg |
| CrCl < 10 | Avoid or specialist supervision |
Pregnancy & Lactation
Pregnancy: Category D
CONTRAINDICATED — fetal renal damage
Lactation: Caution
Top Drug Interactions
| Interacting Drug | Effect | Severity |
|---|---|---|
| NSAIDs | AKI, reduced effect | Major |
| K+ sparing diuretics, K+ | Hyperkalemia | Major |
| ARBs | AVOID combination | Major |
| Lithium | Toxicity | Major |
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Side Effects
Common
- Dry cough (15-20%)
- Dizziness
- Hyperkalemia
- First-dose hypotension
Serious / Discontinue If
- Angioedema
- AKI
- Hyperkalemia
Contraindications
- Pregnancy
- History of ACEi angioedema
- Bilateral RAS
Available Indian Brands
| Brand | Manufacturer | Price (approx) |
|---|---|---|
| Cardace 5 | Sanofi | 10 tab ₹105 |
| Ramistar 5 | Lupin | 10 tab ₹85 |
| Hopace 5 | Cadila | 10 tab ₹78 |
Monitoring Required
- BP, K+, creatinine within 2 weeks, then 3-6 monthly
Patient Counseling Points
- Stop if pregnant
- Persistent cough → switch to ARB
- Avoid OTC NSAIDs
- Report facial swelling
Stop Googling drug references mid-consultation
EasyClinic auto-flags Cardace interactions, renal cutoffs, and pregnancy warnings the moment you write the prescription. Built-in safety net for every Indian doctor.
References
- BNF
- Lexicomp
- Indian National Formulary
- Specialty society guidelines
Disclaimer: This information is for clinical reference only. It is not exhaustive and does not substitute clinical judgement. Always verify current dosing against the manufacturer's prescribing information and current treatment guidelines. Drug prices are approximate and may vary.