Pregeb (Pregabalin)
Also sold as: Pregeb, Lyrica, Pregaba, Maxgalin
Pregnancy
Cat C
Lactation
Caution
Schedule
H1
Forms
Capsule 25/50/75/100/150/300mg
Indications
- Diabetic neuropathy
- Post-herpetic neuralgia
- Fibromyalgia
- Partial seizures (adjunctive)
- Generalized anxiety disorder
Adult Dosing
Neuropathic pain
Start 75 mg BD; titrate to 150-300 mg BD over 1-2 weeks; max 600 mg/day
GAD
75-300 mg BD
Renal Dose Adjustment
| CrCl / eGFR | Dose Adjustment |
|---|---|
| CrCl > 60 | Standard |
| CrCl 30-60 | 50% dose |
| CrCl 15-30 | 25% dose |
| CrCl < 15 | 12.5% (e.g., 25 mg OD) |
Pregnancy & Lactation
Pregnancy: Category C
Lactation: Caution
Top Drug Interactions
| Interacting Drug | Effect | Severity |
|---|---|---|
| Opioids | Severe CNS/respiratory depression — FDA WARNING | Major |
| CNS depressants | Additive sedation | Major |
| Thiazolidinediones (pioglitazone) | Worsened edema/HF | Moderate |
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Side Effects
Common
- Sedation
- Dizziness
- Weight gain
- Edema
- Dry mouth
- Blurred vision
- Euphoria (abuse potential)
Serious / Discontinue If
- Suicidal ideation (FDA warning)
- Severe respiratory depression with opioids
- Angioedema
- Withdrawal seizures on abrupt stop
- Misuse/dependence (Schedule V in USA)
Contraindications
- Hypersensitivity
Available Indian Brands
| Brand | Manufacturer | Price (approx) |
|---|---|---|
| Pregeb 75 | Sun Pharma | 10 cap ₹125 |
| Maxgalin 75 | Sun Pharma | 10 cap ₹95 |
| Lyrica 75 | Pfizer | 14 cap ₹385 |
Monitoring Required
- Mood, weight, edema, signs of misuse
Patient Counseling Points
- Titrate slowly
- Do not combine with opioids/alcohol
- Do not stop abruptly
- Caution driving
Stop Googling drug references mid-consultation
EasyClinic auto-flags Pregeb interactions, renal cutoffs, and pregnancy warnings the moment you write the prescription. Built-in safety net for every Indian doctor.
References
- BNF
- Lexicomp
- Indian National Formulary
- Specialty society guidelines
Disclaimer: This information is for clinical reference only. It is not exhaustive and does not substitute clinical judgement. Always verify current dosing against the manufacturer's prescribing information and current treatment guidelines. Drug prices are approximate and may vary.