Pioglar (Pioglitazone)
Also sold as: Pioglar, Pioz, Glita, Diaglit
Pregnancy
Cat C
Lactation
Avoid
Schedule
H
Forms
Tablet 7.5/15/30mg
Indications
- T2DM (third-line, especially insulin resistance)
- NAFLD/NASH (off-label)
Adult Dosing
T2DM
15-30 mg PO OD; max 45 mg/day
Renal Dose Adjustment
| CrCl / eGFR | Dose Adjustment |
|---|---|
| No adjustment needed | No CrCl-based adjustment |
Hepatic Adjustment
Avoid in active liver disease
Pregnancy & Lactation
Pregnancy: Category C
Lactation: Avoid
Top Drug Interactions
| Interacting Drug | Effect | Severity |
|---|---|---|
| Insulin | Increased fluid retention, HF risk | Major |
| Gemfibrozil | Doubles pioglitazone levels | Moderate |
| Rifampicin | Reduces pioglitazone effect | Moderate |
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Side Effects
Common
- Weight gain
- Edema
- Headache
- Myalgia
Serious / Discontinue If
- Heart failure (fluid retention)
- Bladder cancer (small increased risk — avoid in active/history)
- Bone fractures (especially women)
- Hepatotoxicity
- Macular edema
Contraindications
- NYHA III-IV HF
- Active bladder cancer
- Hematuria (uninvestigated)
- Active liver disease
- Type 1 DM, DKA
Available Indian Brands
| Brand | Manufacturer | Price (approx) |
|---|---|---|
| Pioglar 15 | Sun Pharma | 10 tab ₹65 |
| Pioz 15 | USV | 10 tab ₹55 |
Monitoring Required
- LFT periodically, edema/weight gain, urinalysis annually for hematuria
Patient Counseling Points
- Report rapid weight gain, swelling, breathlessness
- Report blood in urine immediately
- Continue exercise + diet
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EasyClinic auto-flags Pioglar interactions, renal cutoffs, and pregnancy warnings the moment you write the prescription. Built-in safety net for every Indian doctor.
References
- BNF
- Lexicomp
- Indian National Formulary
- Specialty society guidelines
Disclaimer: This information is for clinical reference only. It is not exhaustive and does not substitute clinical judgement. Always verify current dosing against the manufacturer's prescribing information and current treatment guidelines. Drug prices are approximate and may vary.