Crocin / Dolo (Paracetamol (Acetaminophen))
Also sold as: Crocin, Calpol, Dolo-650, P-650, T-98, Pyrigesic
Pregnancy
Cat B
Lactation
Safe
Schedule
OTC
Forms
Tablet 500/650mg +4
Indications
- Fever
- Mild-to-moderate pain
- Headache
- Post-vaccination fever
- Post-operative pain
Adult Dosing
Fever / Pain
500-1000 mg PO every 4-6 hours
Max 4g/day
Severe pain (IV)
1g IV every 6 hours
Pediatric Dosing
Standard antipyretic for children. Available as syrup 120mg/5mL or DS 250mg/5mL.
Renal Dose Adjustment
| CrCl / eGFR | Dose Adjustment |
|---|---|
| CrCl > 50 mL/min | No adjustment |
| CrCl 10-50 mL/min | Increase dosing interval to every 6 hours |
| CrCl < 10 mL/min | Every 8 hours |
Hepatic Adjustment
CAUTION — paracetamol is hepatotoxic in overdose. Reduce to 2-3g/day in chronic liver disease, alcoholic hepatitis. Avoid in acute hepatic failure.
Pregnancy & Lactation
Pregnancy: Category B
First-line analgesic/antipyretic in all trimesters of pregnancy.
Lactation: Safe
Top Drug Interactions
| Interacting Drug | Effect | Severity |
|---|---|---|
| Warfarin | Chronic high doses may increase INR | Moderate |
| Alcohol (chronic) | Increased hepatotoxicity risk | Major |
| Carbamazepine, phenytoin, rifampicin | Increased hepatotoxicity risk via CYP induction | Moderate |
| Cholestyramine | Reduced absorption | Minor |
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Side Effects
Common
- Generally well-tolerated
- Rare: nausea, rash
Serious / Discontinue If
- Hepatotoxicity in overdose (>10g acute, >4g/day chronic)
- SJS/TEN (very rare)
- Acute kidney injury (chronic high-dose)
Contraindications
- Severe hepatic impairment
- Known hypersensitivity
Available Indian Brands
| Brand | Manufacturer | Price (approx) |
|---|---|---|
| Crocin Advance 500 | GSK | 15 tab ₹35 |
| Dolo 650 | Micro Labs | 15 tab ₹30 |
| Calpol 650 | GSK | 15 tab ₹32 |
| P-650 | Aristo | 10 tab ₹18 |
Monitoring Required
- LFT in chronic high-dose use
- Monitor for paracetamol toxicity in suspected overdose
Patient Counseling Points
- Do not exceed 4 g/day or 8 tablets of 500mg
- Avoid combining with other paracetamol-containing products (cold remedies)
- Avoid alcohol during use
- Seek immediate help for suspected overdose (NAC antidote available)
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EasyClinic auto-flags Crocin / Dolo interactions, renal cutoffs, and pregnancy warnings the moment you write the prescription. Built-in safety net for every Indian doctor.
References
- BNF
- Lexicomp Drug Information
- Indian National Formulary
- IAP/RSSDI/CSI Guidelines