Zanocin (Ofloxacin)
Also sold as: Zanocin, Tarivid, Oflox
Pregnancy
Cat C
Lactation
Caution
Schedule
H
Forms
Tablet 200/400mg +3
Indications
- UTI
- Bacterial diarrhea
- PID (with metronidazole)
- Typhoid
- Skin infections
- Eye/ear infections (topical)
Adult Dosing
UTI
200 mg PO BD × 3-7 days
Bacterial diarrhea
200 mg PO BD × 3 days
Typhoid
400 mg PO BD × 7-14 days (resistance now common)
Pediatric Dosing
Age Range: Generally avoid <18y
Dose: Same cautions as ciprofloxacin
Cartilage toxicity risk
Renal Dose Adjustment
| CrCl / eGFR | Dose Adjustment |
|---|---|
| CrCl > 50 | No adjustment |
| CrCl 20-50 | 50% standard dose |
| CrCl < 20 | 50% dose every 24-48 hours |
Pregnancy & Lactation
Pregnancy: Category C
Avoid in pregnancy
Lactation: Caution
Top Drug Interactions
| Interacting Drug | Effect | Severity |
|---|---|---|
| Antacids, iron, calcium | Reduced absorption — separate 2h | Major |
| Warfarin | Increased INR | Moderate |
| Theophylline | Toxicity | Major |
| NSAIDs | Seizure risk | Moderate |
| QT-prolonging drugs | Additive QT | Major |
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Side Effects
Common
- Nausea, diarrhea
- Headache
- Insomnia
- Photosensitivity
Serious / Discontinue If
- Tendon rupture
- C. diff
- QT prolongation
- Aortic dissection
- Peripheral neuropathy
Contraindications
- Quinolone allergy
- Tendinopathy history
Available Indian Brands
| Brand | Manufacturer | Price (approx) |
|---|---|---|
| Zanocin 200 | Ranbaxy | 10 tab ₹85 |
| Oflox 200 | Cipla | 10 tab ₹65 |
| Zenflox-OZ | Ranbaxy | 10 tab ₹125 |
Patient Counseling Points
- Avoid antacids/iron within 2h
- Stop and report tendon pain
- Avoid sun
Stop Googling drug references mid-consultation
EasyClinic auto-flags Zanocin interactions, renal cutoffs, and pregnancy warnings the moment you write the prescription. Built-in safety net for every Indian doctor.
References
- BNF
- Lexicomp
- Indian National Formulary
- Specialty society guidelines
Disclaimer: This information is for clinical reference only. It is not exhaustive and does not substitute clinical judgement. Always verify current dosing against the manufacturer's prescribing information and current treatment guidelines. Drug prices are approximate and may vary.