Naprosyn (Naproxen Sodium)
Also sold as: Naprosyn, Naprox, Xenobid
Pregnancy
Cat C
Lactation
Caution
Schedule
OTC
Forms
Tablet 250/500mg +1
Indications
- OA, RA, AS
- Gout (acute)
- Dysmenorrhea
- Pain
- Migraine
Adult Dosing
Pain
500 mg loading, then 250 mg every 6-8h; max 1.25 g first 24h then 1g/day
Inflammation
500-1000 mg/day in 1-2 doses
Pediatric Dosing
Age Range: >2 years
Dose: 5-7 mg/kg every 8-12h; max 1g/day
Renal Dose Adjustment
| CrCl / eGFR | Dose Adjustment |
|---|---|
| CrCl < 30 | AVOID |
Pregnancy & Lactation
Pregnancy: Category C
Lactation: Caution
Top Drug Interactions
| Interacting Drug | Effect | Severity |
|---|---|---|
| Warfarin, aspirin | Bleeding | Major |
| ACE/ARB/diuretics | AKI | Major |
| Lithium, methotrexate | Toxicity | Moderate |
DoctorScribe — AI Medical Scribe
Stop looking up Naprosyn — just speak the prescription
"Naprosyn as per dose, BD for 5 days." DoctorScribe writes the full prescription with brand, strength, frequency, and route — auto-applies pediatric weight-based dosing and renal adjustments. Try the live demo.
Side Effects
Common
- Dyspepsia
- Nausea
- Headache
- Tinnitus
Serious / Discontinue If
- GI bleed
- AKI
- CV events (lowest CV risk among NSAIDs per CNT meta-analysis)
- Hepatotoxicity
Contraindications
- Active PUD
- Severe CKD/HF
- Hypersensitivity
- 3rd trimester pregnancy
Available Indian Brands
| Brand | Manufacturer | Price (approx) |
|---|---|---|
| Naprosyn 500 | Roche | 10 tab ₹165 |
| Naprox 500 | Cipla | 10 tab ₹95 |
Patient Counseling Points
- Take with food
- Lowest CV risk NSAID — preferred if CV history
- Watch for GI symptoms
Stop Googling drug references mid-consultation
EasyClinic auto-flags Naprosyn interactions, renal cutoffs, and pregnancy warnings the moment you write the prescription. Built-in safety net for every Indian doctor.
References
- BNF
- Lexicomp
- Indian National Formulary
- Specialty society guidelines
Disclaimer: This information is for clinical reference only. It is not exhaustive and does not substitute clinical judgement. Always verify current dosing against the manufacturer's prescribing information and current treatment guidelines. Drug prices are approximate and may vary.