Losar (Losartan Potassium)
Also sold as: Losar, Lozar, Cozaar, Repace
Pregnancy
Cat D
Lactation
Avoid
Schedule
H
Forms
Tablet 25/50/100mg +1
Indications
- Hypertension
- Diabetic nephropathy with proteinuria
- Heart failure (alternative to ACEi)
- Stroke risk reduction in HTN with LVH
Adult Dosing
HTN
50 mg PO OD; titrate to 100 mg
Max 100 mg/day
Renal Dose Adjustment
| CrCl / eGFR | Dose Adjustment |
|---|---|
| No specific dose adjustment by CrCl | Monitor K+ and creatinine |
Hepatic Adjustment
Reduce to 25 mg in mild-moderate hepatic impairment
Pregnancy & Lactation
Pregnancy: Category D
CONTRAINDICATED — fetal renal damage
Lactation: Avoid
Top Drug Interactions
| Interacting Drug | Effect | Severity |
|---|---|---|
| NSAIDs | AKI ("triple whammy" with diuretic), reduced antihypertensive | Major |
| ACEi | AVOID combination | Major |
| K+ sparing diuretics, K+ supplements | Hyperkalemia | Major |
| Lithium | Increased lithium toxicity | Moderate |
| Rifampicin | Reduced losartan effect | Moderate |
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Side Effects
Common
- Dizziness
- Headache
- Hyperkalemia
- Cough (less than ACEi)
Serious / Discontinue If
- Angioedema (rare)
- AKI (renal artery stenosis)
- Hyperkalemia
- Rhabdomyolysis (rare)
Contraindications
- Pregnancy
- Bilateral renal artery stenosis
- Hypersensitivity
Available Indian Brands
| Brand | Manufacturer | Price (approx) |
|---|---|---|
| Losar 50 | Unichem | 15 tab ₹68 |
| Repace 50 | Sun Pharma | 15 tab ₹85 |
| Cozaar 50 | MSD | 14 tab ₹165 |
Monitoring Required
- BP, K+, creatinine within 1-2 weeks of start, then 3-6 monthly
Patient Counseling Points
- Take same time daily
- Stop immediately if pregnant
- Avoid OTC NSAIDs
- Limit potassium supplements
Stop Googling drug references mid-consultation
EasyClinic auto-flags Losar interactions, renal cutoffs, and pregnancy warnings the moment you write the prescription. Built-in safety net for every Indian doctor.
References
- BNF
- Lexicomp Drug Information
- Indian National Formulary
- Specialty society guidelines (RSSDI/CSI/IAP)
Disclaimer: This information is for clinical reference only. It is not exhaustive and does not substitute clinical judgement. Always verify current dosing against the manufacturer's prescribing information and current treatment guidelines. Drug prices are approximate and may vary.