Levoflox (Levofloxacin)
Also sold as: Levoflox, Tavanic, Levomac, L-Cin
Pregnancy
Cat C
Lactation
Caution
Schedule
H
Forms
Tablet 250/500/750mg +2
Indications
- CAP (atypical coverage)
- Sinusitis
- COPD exacerbation
- Complicated UTI
- Pyelonephritis
- Skin and soft tissue infections
- Tuberculosis (MDR-TB regimens)
Adult Dosing
CAP
750 mg PO/IV once daily
5 days
Sinusitis/COPD
500 mg PO once daily
5-7 days
UTI
250-500 mg PO once daily
3-10 days
TB (MDR)
750-1000 mg PO once daily
Combined with other anti-TB drugs
Pediatric Dosing
Safer alternatives preferred
Renal Dose Adjustment
| CrCl / eGFR | Dose Adjustment |
|---|---|
| CrCl > 50 mL/min | No adjustment |
| CrCl 20-49 mL/min | 250-500 mg every 24 hours |
| CrCl < 20 mL/min | 500 mg loading, then 250 mg every 48 hours |
Pregnancy & Lactation
Pregnancy: Category C
Avoid in pregnancy unless no alternative.
Lactation: Caution
Top Drug Interactions
| Interacting Drug | Effect | Severity |
|---|---|---|
| QT-prolonging drugs | Additive QT prolongation | Major |
| Antacids, iron, calcium | Reduced absorption — separate by 2 hours | Major |
| Warfarin | Increased INR | Moderate |
| NSAIDs | Increased seizure risk | Moderate |
| Steroids | Increased tendon rupture risk | Major |
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Side Effects
Common
- Nausea
- Diarrhea
- Headache
- Insomnia
- Photosensitivity
Serious / Discontinue If
- Tendon rupture
- C. difficile colitis
- QT prolongation
- Peripheral neuropathy
- Aortic dissection
- Hypoglycemia in diabetics on sulfonylureas
Contraindications
- Quinolone allergy
- Prior tendinopathy with quinolones
Available Indian Brands
| Brand | Manufacturer | Price (approx) |
|---|---|---|
| Levoflox 500 | Cipla | 5 tab ₹95 |
| Levomac 500 | Macleods | 5 tab ₹85 |
| L-Cin 500 | Lupin | 5 tab ₹105 |
Monitoring Required
- ECG, glucose in diabetics, watch for tendon pain
Patient Counseling Points
- Stop and report tendon pain
- Use sun protection
- Avoid antacids within 2 hours
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EasyClinic auto-flags Levoflox interactions, renal cutoffs, and pregnancy warnings the moment you write the prescription. Built-in safety net for every Indian doctor.
References
- BNF — Levofloxacin
- IDSA CAP Guidelines
- WHO MDR-TB Guidelines