Glynase (Glipizide)
Also sold as: Glynase, Minidiab, Glipizide, Glez
Pregnancy
Cat C
Lactation
Avoid
Schedule
H
Forms
Tablet 5/10mg +1
Indications
- Type 2 DM (when metformin contraindicated/insufficient)
Adult Dosing
T2DM
Start 5 mg PO OD with breakfast; max 40 mg/day in 2 divided doses (XR: 5-20 mg OD)
Renal Dose Adjustment
| CrCl / eGFR | Dose Adjustment |
|---|---|
| eGFR > 50 | Standard |
| eGFR 30-50 | Start low, titrate cautiously |
| eGFR < 30 | AVOID — hypoglycemia risk |
Hepatic Adjustment
Avoid in severe
Pregnancy & Lactation
Pregnancy: Category C
Switch to insulin
Lactation: Avoid
Top Drug Interactions
| Interacting Drug | Effect | Severity |
|---|---|---|
| Beta-blockers | Mask hypoglycemia | Moderate |
| NSAIDs, sulfa, fluconazole | Increased hypoglycemia | Moderate |
| Steroids, thiazides | Hyperglycemia | Moderate |
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Side Effects
Common
- Hypoglycemia
- Weight gain (less than glyburide)
- Nausea
Serious / Discontinue If
- Severe hypoglycemia (especially in elderly, CKD)
- Hemolytic anemia (G6PD)
- SIADH
Contraindications
- T1DM, DKA
- Severe hepatic/renal impairment
- Sulfa allergy
Available Indian Brands
| Brand | Manufacturer | Price (approx) |
|---|---|---|
| Glynase 5 | USV | 15 tab ₹35 |
| Glez 5 | Eris | 15 tab ₹38 |
Monitoring Required
- HbA1c, fasting glucose, eGFR
Patient Counseling Points
- Take with breakfast
- Carry glucose tablets
- Recognize hypo symptoms
Stop Googling drug references mid-consultation
EasyClinic auto-flags Glynase interactions, renal cutoffs, and pregnancy warnings the moment you write the prescription. Built-in safety net for every Indian doctor.
References
- BNF
- Lexicomp
- Indian National Formulary
- Specialty society guidelines
Disclaimer: This information is for clinical reference only. It is not exhaustive and does not substitute clinical judgement. Always verify current dosing against the manufacturer's prescribing information and current treatment guidelines. Drug prices are approximate and may vary.