Amaryl (Glimepiride)
Also sold as: Amaryl, Glimepride, Glimer, Glimy
Pregnancy
Cat C
Lactation
Avoid
Schedule
H
Forms
Tablet 1/2/3/4mg +1
Indications
- Type 2 DM (add-on to metformin)
- Monotherapy if metformin contraindicated
Adult Dosing
T2DM
Start 1-2 mg PO OD with breakfast; titrate by 1-2 mg every 1-2 weeks
Max 8 mg/day
Renal Dose Adjustment
| CrCl / eGFR | Dose Adjustment |
|---|---|
| eGFR > 60 | No adjustment |
| eGFR 30-60 | Start at 1 mg, titrate cautiously |
| eGFR < 30 | AVOID — high hypoglycemia risk |
Hepatic Adjustment
Avoid in severe hepatic impairment
Pregnancy & Lactation
Pregnancy: Category C
Switch to insulin in pregnancy.
Lactation: Avoid
Top Drug Interactions
| Interacting Drug | Effect | Severity |
|---|---|---|
| Beta-blockers | Mask hypoglycemia | Moderate |
| Sulfonamides, fluconazole, warfarin | Increased hypoglycemia | Moderate |
| Steroids, thiazides | Reduced glycemic control | Moderate |
| Alcohol | Hypoglycemia, disulfiram-like reaction (rare) | Major |
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Side Effects
Common
- Hypoglycemia
- Weight gain
- Nausea
- Dizziness
Serious / Discontinue If
- Severe hypoglycemia (especially in elderly, CKD)
- Hemolytic anemia (G6PD deficiency)
- SIADH (rare)
- Cholestatic jaundice
Contraindications
- Type 1 DM, DKA
- Severe hepatic/renal impairment
- Sulfa allergy
- Pregnancy/lactation
Available Indian Brands
| Brand | Manufacturer | Price (approx) |
|---|---|---|
| Amaryl 2 | Sanofi | 10 tab ₹85 |
| Glimepride 2 | Cipla | 10 tab ₹65 |
| Glimer 2 | Lupin | 10 tab ₹55 |
Monitoring Required
- HbA1c every 3 months, fasting glucose, eGFR
Patient Counseling Points
- Take with breakfast
- Always carry glucose tablets
- Recognize hypo symptoms
- Inform doctor of any other new medications
Stop Googling drug references mid-consultation
EasyClinic auto-flags Amaryl interactions, renal cutoffs, and pregnancy warnings the moment you write the prescription. Built-in safety net for every Indian doctor.
References
- BNF
- Lexicomp Drug Information
- Indian National Formulary
- Specialty society guidelines (RSSDI/CSI/IAP)
Disclaimer: This information is for clinical reference only. It is not exhaustive and does not substitute clinical judgement. Always verify current dosing against the manufacturer's prescribing information and current treatment guidelines. Drug prices are approximate and may vary.