EasyClinic Drug Reference

Indian clinical drug database

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All Drugs

Diuretic · Loop diuretic

Lasix (Furosemide (Frusemide))

Also sold as: Lasix, Frusemide, Frusenex, Dytor (torsemide)

Pregnancy

Cat C

Lactation

Caution

Schedule

Forms

Tablet 40mg +1

Indications

Acute pulmonary edema
Heart failure (chronic)
Edema (renal, hepatic)
Hypertension (when CrCl <30)
Hyperkalemia
Hypercalcemia

Adult Dosing

Edema (oral)

20-80 mg PO OD-BD; titrate to response

Max 600 mg/day

Acute pulmonary edema

20-40 mg IV slow push, repeat every 1-2 hours

CKD with edema

May require higher doses (40-200 mg) due to reduced delivery

Maximum daily dose: 600 mg/day (typical max in CKD)

Pediatric Dosing

Age Range: All ages

Dose: 1-2 mg/kg PO OD-BD; max 6 mg/kg/day

IV: 0.5-1 mg/kg

Renal Dose Adjustment

CrCl / eGFR	Dose Adjustment
CrCl < 20	Higher doses needed (up to 200 mg) due to reduced tubular secretion

Calculate eGFR / CrCl →

Hepatic Adjustment

Caution — risk of hepatic encephalopathy

Pregnancy & Lactation

Pregnancy: Category C

Lactation: Caution

May suppress lactation

Top Drug Interactions

Interacting Drug	Effect	Severity
Aminoglycosides, Vancomycin	Ototoxicity, nephrotoxicity	Major
NSAIDs	Reduced diuretic effect, AKI	Major
Digoxin	Hypokalemia → digoxin toxicity	Major
Lithium	Lithium toxicity	Major
ACEi/ARB	Symptomatic hypotension on initiation	Moderate

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Side Effects

Common

Hypokalemia
Hypomagnesemia
Hypotension
Hyperuricemia
Hyperglycemia
Dehydration

Serious / Discontinue If

Severe electrolyte/volume depletion
Ototoxicity (rapid IV high-dose)
AKI
SJS, TEN
Pancreatitis

Contraindications

Anuria
Severe hypovolemia
Sulfonamide hypersensitivity

Available Indian Brands

Brand	Manufacturer	Price (approx)
Lasix 40	Sanofi	15 tab ₹35
Frusenex 40	Cipla	15 tab ₹28
Dytor 10 (torsemide)	Cipla	10 tab ₹95

Monitoring Required

Daily weight in HF, electrolytes (K, Mg, Na), creatinine, BP

Patient Counseling Points

Take in morning to avoid nocturia
Stand up slowly
Watch for muscle cramps, weakness
Daily weight log if HF
Eat banana, coconut water for K+

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References

BNF
Lexicomp Drug Information
Indian National Formulary
Specialty society guidelines (RSSDI/CSI/IAP)

Disclaimer: This information is for clinical reference only. It is not exhaustive and does not substitute clinical judgement. Always verify current dosing against the manufacturer's prescribing information and current treatment guidelines. Drug prices are approximate and may vary.