Fenofibrate (Fenofibrate)
Also sold as: Lipidil, Triglide, Fenocor
Pregnancy
Cat C
Lactation
Avoid
Schedule
OTC
Forms
Capsule 48mg, 145mg, 160mg +1
Indications
- Hypertriglyceridemia (Types IV and V)
- Primary dyslipidemia
- Mixed dyslipidemia
- Adjunctive to statin for triglyceride reduction
Adult Dosing
Hypertriglyceridemia
145-160 mg PO once daily with meals
Daily
Type IV/V hypertriglyceridemia
145-160 mg daily (adjusted based on response)
Long-term
Pediatric Dosing
Avoid in pediatric patients
Renal Dose Adjustment
| CrCl / eGFR | Dose Adjustment |
|---|---|
| CrCl > 60 mL/min | No adjustment |
| CrCl 40-60 mL/min | 100 mg once daily (or skip doses) |
| CrCl < 40 mL/min | Contraindicated |
Hepatic Adjustment
Severe hepatic impairment: contraindicated. Monitor LFT baseline and 12 weeks.
Pregnancy & Lactation
Pregnancy: Category C
Limited data; use only if clearly necessary for triglyceride control.
Lactation: Avoid
Unknown excretion; avoid due to potential risk.
Top Drug Interactions
| Interacting Drug | Effect | Severity |
|---|---|---|
| Statins (especially simvastatin, pravastatin) | Increased myopathy and rhabdomyolysis risk (avoid combination if possible) | Major |
| Warfarin | Enhanced anticoagulant effect; increase INR risk | Major |
| Colchicine | Increased colchicine toxicity | Moderate |
| Cyclosporine | Increased fenofibrate levels | Moderate |
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Side Effects
Common
- Myalgia
- Dyspepsia
- Nausea
- Increased liver enzymes
- Elevated uric acid
Serious / Discontinue If
- Myopathy / rhabdomyolysis (especially with statin)
- Gallstones / cholelithiasis
- Hepatotoxicity
- Acute renal failure
- Hypersensitivity syndrome
Contraindications
- Severe renal impairment (CrCl <40 mL/min)
- Severe hepatic impairment
- Gallbladder disease
- Primary biliary cirrhosis
- Concurrent statin therapy (if possible)
Available Indian Brands
| Brand | Manufacturer | Price (approx) |
|---|---|---|
| Lipidil 145 | Abbvie | 10 cap ₹220 |
| Triglide 145 | Cipla | 10 cap ₹150 |
| Fenocor 160 | Intas | 10 tab ₹130 |
Monitoring Required
- LFT at baseline, 12 weeks, then annually
- Lipid panel 4-12 weeks
- CK if muscle pain
- Renal function (baseline and periodic)
- Uric acid (gout risk)
- INR if on warfarin
Patient Counseling Points
- Take with meals to reduce GI upset
- Report muscle pain, weakness, or dark urine immediately
- Regular liver and kidney function tests required
- Avoid statins if possible due to myopathy risk
- Watch for signs of gallbladder disease (RUQ pain)
- Inform doctor of all medications
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Clinically reviewed by: Dr. Rajesh Choudhury, MD (Cardiology), Preventive Care Specialist
Last reviewed: 2026-04-12
References
- BNF — Fenofibrate
- AHA Triglyceride Guidelines 2023
- Indian Fibrate Registry