Plavix (Clopidogrel Bisulfate)
Also sold as: Plavix, Clopilet, Deplatt, Clopidax
Pregnancy
Cat B
Lactation
Avoid
Schedule
H
Forms
Tablet 75/150/300mg +1
Indications
- Post-PCI / drug-eluting stent (with aspirin)
- Acute coronary syndrome
- Recent MI / ischemic stroke / PAD
- Aspirin-intolerant patients
Adult Dosing
Maintenance
75 mg PO once daily
ACS / PCI loading
300-600 mg loading, then 75 mg/day
Renal Dose Adjustment
| CrCl / eGFR | Dose Adjustment |
|---|---|
| No adjustment needed | No CrCl-based dose adjustment required |
Hepatic Adjustment
Caution in severe hepatic impairment
Pregnancy & Lactation
Pregnancy: Category B
Limited data; use only if clearly needed.
Lactation: Avoid
Top Drug Interactions
| Interacting Drug | Effect | Severity |
|---|---|---|
| Omeprazole, Esomeprazole | AVOID — significantly reduce clopidogrel efficacy. Use pantoprazole instead | Major |
| Anticoagulants (warfarin, DOACs) | Major bleeding risk | Major |
| NSAIDs | GI bleed risk | Major |
| CYP2C19 inhibitors (fluconazole, fluoxetine) | Reduced clopidogrel activation | Moderate |
| Repaglinide | Hypoglycemia | Moderate |
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Side Effects
Common
- Bleeding (epistaxis, bruising)
- Dyspepsia
- Diarrhea
- Rash
Serious / Discontinue If
- GI bleeding
- Intracranial hemorrhage
- TTP (rare, within 2 weeks of starting)
- Severe neutropenia (rare)
Contraindications
- Active bleeding
- Severe hepatic impairment
- Hypersensitivity
Available Indian Brands
| Brand | Manufacturer | Price (approx) |
|---|---|---|
| Clopilet 75 | Sun Pharma | 15 tab ₹65 |
| Deplatt 75 | Torrent | 15 tab ₹70 |
| Plavix 75 | Sanofi | 14 tab ₹185 |
| Clopidax 75 | Cipla | 15 tab ₹65 |
Monitoring Required
- Hemoglobin if symptoms
- Bleeding
Patient Counseling Points
- Take same time daily
- Inform all doctors and dentists before procedures (stop 5-7 days before elective surgery if instructed)
- Report unusual bleeding
- Avoid omeprazole — use pantoprazole if PPI needed
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EasyClinic auto-flags Plavix interactions, renal cutoffs, and pregnancy warnings the moment you write the prescription. Built-in safety net for every Indian doctor.
References
- BNF
- Lexicomp Drug Information
- Indian National Formulary
- Specialty society guidelines (RSSDI/CSI/IAP)
Disclaimer: This information is for clinical reference only. It is not exhaustive and does not substitute clinical judgement. Always verify current dosing against the manufacturer's prescribing information and current treatment guidelines. Drug prices are approximate and may vary.