EasyClinic Drug Reference

Indian clinical drug database

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Antibiotic · 3rd generation cephalosporin (oral)

Taxim-O (Cefixime)

Also sold as: Taxim-O, Suprax, Mahacef, Topcef

Pregnancy

Cat B

Lactation

Safe

Schedule

Forms

Tablet 100/200mg +2

Indications

Uncomplicated UTI
Typhoid fever
Acute otitis media
Pharyngitis/tonsillitis
Acute bronchitis exacerbations
Uncomplicated gonorrhea

Adult Dosing

Most infections

200 mg PO BD or 400 mg PO OD

7 days

Typhoid fever

400 mg PO BD

14 days

Gonorrhea (uncomplicated)

400 mg PO single dose

Combine with azithromycin 1g

Maximum daily dose: 400 mg/day

Pediatric Dosing

Age Range: >6 months

Dose: 8 mg/kg/day OD or divided BD

Max/day: 400 mg/day

For AOM: 8 mg/kg/day × 5 days

Calculate exact mL by weight →

Renal Dose Adjustment

CrCl / eGFR	Dose Adjustment
CrCl > 60 mL/min	No adjustment
CrCl 21-60 mL/min	75% of normal dose
CrCl < 20 mL/min	50% of normal dose

Calculate eGFR / CrCl →

Pregnancy & Lactation

Pregnancy: Category B

Lactation: Safe

Top Drug Interactions

Interacting Drug	Effect	Severity
Warfarin	Increased INR	Moderate
Carbamazepine	Increased carbamazepine levels	Moderate
Antacids	No significant interaction	Minor

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Side Effects

Common

Diarrhea
Abdominal pain
Nausea
Headache

Serious / Discontinue If

C. difficile colitis
Anaphylaxis
SJS/TEN (rare)

Contraindications

Cephalosporin hypersensitivity
Severe penicillin allergy (cross-reactivity ~5-10%)

Available Indian Brands

Brand	Manufacturer	Price (approx)
Taxim-O 200	Alkem	10 tab ₹165
Mahacef 200	Mankind	10 tab ₹125
Topcef 200	Aristo	10 tab ₹110
Cefolac 200	Macleods	10 tab ₹118

Patient Counseling Points

Can be taken with or without food
Complete the full course
Report severe diarrhea

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References

BNF — Cefixime
WHO STG Typhoid
IAP Guidelines AOM

Disclaimer: This information is for clinical reference only. It is not exhaustive and does not substitute clinical judgement. Always verify current dosing against the manufacturer's prescribing information and current treatment guidelines. Drug prices are approximate and may vary.