Concor (Bisoprolol Fumarate)
Also sold as: Concor, Bisocard, Corbis, Bisol, Cardisel
Pregnancy
Cat C
Lactation
Caution
Schedule
H
Forms
Tablet 2.5mg, 5mg, 10mg
Indications
- Heart failure with reduced ejection fraction (HFrEF)
- Hypertension
- Stable angina
- Rate control in atrial fibrillation
- Post-myocardial infarction (cardioprotection)
Adult Dosing
Heart failure (HFrEF)
Start 1.25 mg PO once daily; double every 2 weeks to target 10 mg/day
Up-titrate slowly; target dose 10 mg/day
Hypertension / Angina
5-10 mg PO once daily
Indefinite
Atrial fibrillation (rate control)
2.5-10 mg PO once daily
Titrate to resting HR < 80 bpm
Pediatric Dosing
Limited pediatric data; specialist guidance required
Renal Dose Adjustment
| CrCl / eGFR | Dose Adjustment |
|---|---|
| CrCl > 20 mL/min | No adjustment |
| CrCl < 20 mL/min | Max 10 mg/day; titrate cautiously |
Hepatic Adjustment
Start with 2.5 mg/day; max 10 mg/day in severe hepatic impairment
Pregnancy & Lactation
Pregnancy: Category C
Avoid in 1st trimester; if used, monitor fetus for bradycardia, hypoglycemia, growth restriction. Discontinue 2-3 days before delivery if possible.
Lactation: Caution
Excreted in breast milk; monitor infant for bradycardia. Use with caution.
Top Drug Interactions
| Interacting Drug | Effect | Severity |
|---|---|---|
| Verapamil / Diltiazem (IV) | Severe bradycardia, AV block, cardiac arrest — avoid IV combination | Major |
| Clonidine | Rebound hypertension if clonidine withdrawn first | Major |
| Insulin / Oral hypoglycaemics | Masks hypoglycaemia symptoms (except sweating) | Moderate |
| NSAIDs | Blunts antihypertensive effect | Moderate |
| Antiarrhythmics (amiodarone) | Additive bradycardia and AV block | Major |
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Side Effects
Common
- Fatigue
- Bradycardia
- Cold extremities
- Dizziness
- Sleep disturbance
Serious / Discontinue If
- Severe bradycardia / AV block
- Bronchospasm (high-dose, less than non-selective)
- Worsening heart failure (if up-titrated too fast)
- Hypoglycaemia masking
Contraindications
- Cardiogenic shock
- Decompensated heart failure
- Sick sinus syndrome / 2nd-3rd degree AV block (without pacemaker)
- Severe bradycardia (HR < 50 bpm)
- Severe asthma / COPD (relative)
- Prinzmetal angina
Available Indian Brands
| Brand | Manufacturer | Price (approx) |
|---|---|---|
| Concor 5 | Merck | 14 tab ₹95 |
| Corbis 5 | Sun Pharma | 14 tab ₹72 |
| Bisocard 5 | Cipla | 14 tab ₹68 |
| Bisol 5 | Lupin | 14 tab ₹65 |
Monitoring Required
- Heart rate (target 55-65 bpm in HF)
- Blood pressure
- Signs of decompensation in HF
- Blood glucose in diabetics
Patient Counseling Points
- NEVER stop abruptly — taper over 1-2 weeks to avoid rebound angina/hypertension
- Take at same time daily, with or without food
- Check pulse before each dose; hold if < 50 bpm and call doctor
- Avoid OTC NSAIDs (ibuprofen, naproxen) — reduce efficacy
- Diabetics: beta-blockers can mask low blood sugar symptoms
Stop Googling drug references mid-consultation
EasyClinic auto-flags Concor interactions, renal cutoffs, and pregnancy warnings the moment you write the prescription. Built-in safety net for every Indian doctor.
Clinically reviewed by: Dr. Priya Sharma, DM (Cardiology), Senior Cardiologist
Last reviewed: 2026-04-01
References
- BNF — Bisoprolol
- ESC Heart Failure Guidelines 2023
- JNC 8 Hypertension Guidelines
- CIBIS-II Trial