Alfoo (Alfuzosin Hydrochloride)
Also sold as: Alfoo, Uroxatral, Xatral, Alfu, Alfusin
Pregnancy
Cat N/A
Lactation
Unknown
Schedule
H
Forms
Tablet IR 2.5mg +2
Indications
- Benign prostatic hyperplasia (BPH) — LUTS
- Ureteric colic / stone expulsion (medical expulsive therapy)
Adult Dosing
BPH (SR)
5 mg PO BD after meals
Ongoing
BPH (XL)
10 mg PO once daily after the same meal
Ongoing — preferred for once-daily convenience
Ureteric stone expulsion
10 mg PO XL once daily
4 weeks or until stone passes
Pediatric Dosing
Adult indication only
Renal Dose Adjustment
| CrCl / eGFR | Dose Adjustment |
|---|---|
| CrCl 30-80 mL/min | No adjustment; use cautiously |
| CrCl < 30 mL/min | Start 2.5 mg BD; increase cautiously |
Hepatic Adjustment
AVOID in moderate-severe hepatic impairment (reduced first-pass metabolism increases bioavailability)
Pregnancy & Lactation
Pregnancy: Category N/A
Male medication only
Lactation: Unknown
Male medication only
Top Drug Interactions
| Interacting Drug | Effect | Severity |
|---|---|---|
| PDE-5 inhibitors (sildenafil, tadalafil) | Significant additive hypotension — avoid combination or use with extreme caution | Major |
| Other antihypertensives | Additive hypotension | Moderate |
| CYP3A4 inhibitors (ketoconazole, ritonavir) | CONTRAINDICATED — substantially increase alfuzosin levels | Major |
| Other alpha-blockers | Do not combine | Major |
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Side Effects
Common
- Dizziness (orthostatic)
- Headache
- Fatigue
- Nausea
- Hypotension
Serious / Discontinue If
- First-dose hypotension / syncope
- QT prolongation (alfuzosin has mild QT-prolonging potential — monitor in at-risk patients)
- Intraoperative floppy iris syndrome (IFIS) — inform ophthalmologist before cataract surgery
- Priapism (rare)
Contraindications
- Severe hepatic impairment
- Concurrent strong CYP3A4 inhibitors
- History of postural hypotension
- Angina (controlled-release nitrates — worsens hypotension)
Available Indian Brands
| Brand | Manufacturer | Price (approx) |
|---|---|---|
| Alfoo 10mg XL | Intas | 15 tab ₹165 |
| Xatral 10mg XL | Sanofi | 10 tab ₹185 |
| Alfu 10mg | Cipla | 15 tab ₹148 |
| Alfusin 10mg | Sun Pharma | 15 tab ₹135 |
Monitoring Required
- Blood pressure (orthostatic)
- IPSS symptom score
- Post-void residual volume
- ECG if QT prolongation risk factors present
Patient Counseling Points
- Take XL tablet with the evening meal — same time daily
- Swallow XL/SR tablet whole — do not crush or chew
- First dose: sit quietly for a few hours (dizziness/fainting risk)
- Rise slowly from bed or chair
- ⚠️ Inform eye surgeon about alfuzosin before cataract operation — IFIS risk
- Avoid driving until response to first dose is known
Stop Googling drug references mid-consultation
EasyClinic auto-flags Alfoo interactions, renal cutoffs, and pregnancy warnings the moment you write the prescription. Built-in safety net for every Indian doctor.
Clinically reviewed by: Dr. Rajiv Nair, MCh (Urology), Consultant Urologist
Last reviewed: 2026-04-01
References
- BNF — Alfuzosin
- EAU BPH Guidelines 2023
- EAU Urolithiasis Guidelines 2023